Clinical Efficacy of Tongqiao Huoxuetang in Treating Blood Stasis Type Vascular Cognitive Impairment
10.13422/j.cnki.syfjx.20182324
- VernacularTitle: 通窍活血汤治疗瘀血内阻型血管性认知障碍的临床观察
- Author:
Yun-he ZHU
1
;
Yun-hu WU
2
;
Xiang FANG
2
Author Information
1. Anhui University of Chinese Medicine, Hefei 230000, China
2. First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230000, China
- Publication Type:Research Article
- Keywords:
vascular cognitive impairment;
Tongqiao Huoxuetang;
magnetic resonance perfusion imaging;
homocysteine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(2):139-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to observe the clinical efficacy of Tongqiao Huoxuetang in treating blood stasis resistance type vascular cognitive impairment, and explore its mechanism of action. Method:A total of 60 patients who met the inclusion standards and were diagnosed as blood stasis resistance type vascular cognitive impairment were randomly divided into treatment group and control group, 30 patients in each group. Donepezil hydrochloride was administered orally in control group based on internal medicine treatment at an initial dose of 5 mg/day, changed to 10 mg/day 4 weeks later. Patients in treatment group additionally received Tongqiao Huoxuetang based on donepezil hydrochloride. Both groups were treated for 3 months. Changes of symptoms were assessed by syndrome scores; cognitive function was assessed by the mini-mental scale (MMSE); daily living ability was assessed by the activity of daily living scale (ADL), and changes of local blood perfusion (CBF value) was assessed by brain magnetic resonance perfusion imaging arterial spin labeling (MRI-ASL). Changes of homocysteine levels in plasma were measured by using an automated biochemical analyzer. Result:① The values of traditional Chinese medicine(TCM) syndrome scores (SDSVD) were significantly improved in both groups after treatment, and the improvement was more obvious than that of control group (P<0.05). ② The cognitive ability and daily living ability of the patients were significantly improved; the MMSE scores and ADL scores were improved significantly in both groups after treatment (P<0.01), and improvement in treatment group was more obvious than that of control group (P<0.05). ③The CBF value in treatment group was significantly higher after treatment (P< 0.05), and also higher than that in control group (P <0.01). ④ Homocysteine level in plasma of treatment group was significantly lower than that of control group (P <0.05). Conclusion:The combination of Tongqiao Huoxuetang combined with donepezil hydrochloride can effectively improve the cognitive ability and daily living ability of the patients with vascular dementia, improve the cerebral blood flow perfusion and decrease the level of homocysteine, so it is worth popularizing in clinical practice.
