Molecular Mechanism of Banxia Baizhu Tianma Tang in Treating Hypertension Based on Integrated Pharmacological Platform
10.13422/j.cnki.syfjx.20182013
- VernacularTitle: 基于整合药理学平台探究半夏白术天麻汤治疗高血压的分子机制
- Author:
Nan XU
1
;
Liang WANG
1
;
Hai-yan SHI
2
;
Xiao-yu LI
1
;
Cheng-bo ZHANG
3
;
Rong SUN
4
Author Information
1. Shandong Academy of Chinese Medicine, Ji'nan 250014, China
2. Shandong Provincial Qianfoshan Hospital, Ji'nan 250014, China
3. Postdoctoral Mobile Station of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China
4. Institute of Advanced Medical Sciences, Shandong University, Ji'nan 250012, China
- Publication Type:Research Article
- Keywords:
Banxia Baizhu Tianma Tang;
hypertension;
integrated pharmacology;
mechanism;
database;
glucose kinase;
nervous system
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(2):109-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the molecular mechanism of Banxia Baizhu Tianma Tang in treating hypertension. Method:Based on an internet-based computation platform for integrated pharmacology of traditional Chinese medicine(TCM),TCM prescription database,TCM database,TCM component database and disease/symptoms target database,information on the chemical compositions contained in TCM was retrieved,an interaction network between potential targets and disease targets of Banxia Baizhu Tianma Tang was built,then core target was enriched and calculated,gene function and pathway analysis was carried out,the multi-dimensional relationship network of "Chinese herbs-ingredients-critical targets-key pathways" of Banxia Baizhu Tianma Tang was further constructed. Result:A total of 90 active ingredients in Banxia Baizhu Tianma Tang were obtained,including alkaloids,nucleosides,flavonoids,saponins,organic acids and other ingredients;they involved 287 core targets,including 13 direct targets,such as adenylate cyclase,G protein coupled with β1 receptor,glucose kinase,etc;they also involved nervous system,endocrine system,circulatory system,estrogen signaling pathway,chemokine signaling pathway and other related biological processes and signaling pathways. Conclusion:Banxia Baizhu Tianma Tang can regulate neurotransmitter concentration and activity abnormalities,improve the protective effect of vascular endothelial cells by improving insulin resistance,regulating the production of inflammatory factors,and inhibiting inflammatory reactions,thereby exerting pharmacological effects on the treatment of hypertension.This study can provide a scientific basis for comprehensive interpretation of mechanism of Banxia Baizhu Tianma Tang.
