Analysis of Molecular Mechanism of Dingxiang Shiditang for Hiccup and Vomit Based on Integrated Pharmacology
10.13422/j.cnki.syfjx.20182307
- VernacularTitle: 基于整合药理学分析丁香柿蒂汤降逆止呃的分子机制
- Author:
Fang-fang DING
1
;
Xiu-juan PENG
1
;
Wen-qiang TANG
1
;
Rui-rui ZHANG
1
;
Feng LIU
1
Author Information
1. Shaanxi Institute of International Trade & Commerce, Xianyang 712046, China
- Publication Type:Research Article
- Keywords:
classical formula;
Dingxiang Shiditang;
integrated pharmacology;
hiccup;
mechanism of action;
nervous system;
nucleotide metabolism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(3):100-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The classical formula of Dingxiang Shiditang can be used for hiccup and vomit which caused by many reasons,its molecular mechanism of this formula was investigated.Method: Based on the integrated pharmacology platform of traditional Chinese medicine,the potential molecular mechanism of Dingxiang Shiditang was revealed from the dimensions of multi-components and multi-targets.Result: There were 89 compounds related to hiccup and vomit of Dingxiang Shiditang,and there was 1 common target[cannabinoid receptor 1(CNR1)].On the one hand,CNR1 could inhibit the occurrence of hiccup and vomit by inhibiting the release of γ-aminobutyric acid(GABA),dopamine,5-hydroxytryptamine(5-HT);on the other hand,CNR1 could inhibit gastrointestinal motility and delay gastric emptying,and it was speculated that CNR1 may play a role in regulating gastrointestinal motility through brain-gut axis.Meanwhile,the mechanism of Dingxiang Shiditang may be related to nucleotide metabolism and nervous system.Conclusion: Dingxiang Shiditang may regulate gastrointestinal motility by affecting the release of neurotransmitters,mitochondrial energy metabolism,and achieve its effect on hiccup and vomit based on the joint intervention of multiple targets and multiple pathways.
