Expression of three common serum enzymes in patients with hepatitis B related hepatocellular carcinoma
10.3760/cma.j.issn.1008-6706.2019.09.018
- VernacularTitle: 三种常见血清肝酶在乙型肝炎相关性肝癌中表达的价值研究
- Author:
Hua CHEN
1
Author Information
1. Department of Infection, Tongji Huangzhou Hospital, Huazhong University of Science and Technology, Huanggang, Hubei 438000, China
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Hepatitis B virus;
Alanine transaminase;
Aspartate kinase;
γ
-Glutamyltransferase;
Serological indicators;
ROC curve;
Sensitivity;
Specificity
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(9):1097-1100
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical value of alanine aminotransferase(ALT), aspartate aminotransferase(AST) and gamma-glutamine transpeptidase(GGT) in the diagnosis of hepatitis B-related hepatocellular carcinoma, and to provide reference for clinical diagnosis.
Methods:From November 2015 to November 2017, 118 patients with hepatitis B-related primary liver cancer (hepatitis B-related primary liver cancer group) admitted to Tongji Huangzhou Hospital of Huazhong University of Science and Technology were selected.And 116 patients with cirrhosis (hepatocirrhosis group) and 114 healthy people were selected as control group.The levels of ALT, AST and GGT and the specificity and sensitivity of each index were compared among the three groups, and the ROC curve was analyzed.
Results:The levels of serum ALT, AST and GGT in the hepatitis B-related primary hepatocellular carcinoma group were higher than those in the cirrhosis group and the control group, and the above serum indicators in the cirrhosis group were higher than those in the control group[(267.1±131.5)U/L vs.(31.2±11.3)U/L vs.(17.4±4.6)U/L, (76.6±23.2)U/L vs.(45.2±13.1)U/L vs.(24.3±6.6)U/L, (125.3±42.6)U/L vs.(53.1±17.6)U/L vs.(22.4±4.4)U/L, all P<0.05]. ROC curve showed that the area under GGT curve was 0.85, under ALT curve was 0.78, and under AST curve was 0.73, the area under the combined diagnostic curve of the three indicators was 0.95.The sensitivity and specificity of three combined diagnosis were higher than those of ALT, AST and GGT.
Conclusion:The levels of serum ALT, AST and GGT in patients with hepatitis B-related primary liver cancer are elevated, and the combined diagnosis of the three indicators has high sensitivity and specificity, which is worthy of clinical reference.
