Advances in the research of effects of competing endogenous RNAs and their regulatory networks in pathological scars of skin
10.3760/cma.j.issn.1009-2587.2019.09.011
- VernacularTitle: 竞争性内源RNA及其调控网络在皮肤病理性瘢痕中的作用研究进展
- Author:
Min LI
1
;
Dewu LIU
2
;
Wan LEI
3
Author Information
1. Department of Gynecology and Obstetrics, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
2. Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
3. Department of Science and Technology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
- Publication Type:Review
- Keywords:
Ribonucleases;
Cicatrix;
Competing endogenous ribonucleic acid
- From:
Chinese Journal of Burns
2019;35(9):701-704
- CountryChina
- Language:Chinese
-
Abstract:
The skin pathologic scar is a skin fibrous proliferative disease characterized by abnormal proliferation of fibroblasts and overdeposition of extracellular matrix. Unclarity of genesis and development mechanism is the main reason that restricts its diagnosis and treatment. In recent years, it has been found that microRNAs play important roles in the regulation mechanism of pathological scars. The competing endogenous RNAs (ceRNAs) have microRNA response elements which can be competitively combined with microRNAs through sponge adsorption. Through the mutual regulation of RNAs, ceRNAs regulate the expression of target gene and participate in the development of disease. Based on the ceRNA hypothesis, this paper systematically reviews the biological functions and clinical significance of ceRNAs in pathological scars of skin, and discusses the role of ceRNAs and " RNA-microRNA-RNA" regulation network in pathologic scars. The ceRNA therapy may become a new model therapy for skin scars in the future.
