Clinical value of matrix metalloproteinase-3 in rheumatic immune disease
10.3760/cma.j.issn.1009-9158.2019.09.003
- VernacularTitle: 基质金属蛋白酶3在风湿免疫性疾病中的临床价值
- Author:
Xiaohui CHEN
1
;
Liyan CUI
Author Information
1. Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China
- Publication Type:Journal Article
- Keywords:
Autoimmune diseases;
Rheumatic diseases;
Matrix metalloproteinase 3;
Tissue inhibitor of metalloproteinases;
Biomarkers
- From:
Chinese Journal of Laboratory Medicine
2019;42(9):731-736
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatic immune disease is a kind of disease caused by the abnormal of autoimmune system, the pathogenesis is complex and affected by many factors. Matrix metalloproteinases are a kind of proteolytic enzyme that can degrade extracellular matrix components, while the matrix metalloproteinase3 is the main enzyme that promote their degradation. In recent years, studies have found that matrix metalloproteinase-3 participates in the development of rheumatic immune disease. It is a potential marker not only can reflect the activity of some diseases, but also to evaluate therapeutic effect.
