lincRNA-p21 and malignant tumors of digestive system
10.3872/j.issn.1007-385x.2019.11.014
- VernacularTitle:lincRNA-p21与消化系统恶性肿瘤
- Author:
YIN Hongzhen
1
;
CHAO Xu
2
;
HUANG Feng
3
Author Information
1. Shaanxi University of traditional Chinese Medicine. First Clinical Medical College
2. Department of Pathology, College of basic Medicine
3. Department of Hepatology, affiliated Hospital of Shaanxi University of traditional Chinese Medicine
- Publication Type:Review
- Keywords:
lncRNAs；lincRNA-p21；消化系统；恶性肿瘤
- From:
Chinese Journal of Cancer Biotherapy
2019;26(11):1270-1274
- CountryChina
- Language:Chinese
-
Abstract:
基因间的长链非编码RNA-p21（long intergenic non-coding RNA，lincRNA-p21）是lncRNAs中的一种，可通过发挥多种 生物学功能影响肿瘤的增殖、转移、侵袭，并且对放、化疗的敏感度产生影响。lincRNA-p21在胃癌、肝癌、结直肠癌的进展中充当 肿瘤抑制基因；也有研究发现lincRNA-p21在常氧条件下无抑癌作用，而在乏氧条件下能抑制乏氧肿瘤细胞增殖；其能够通过抑 制β-连环蛋白信号转导的活性，从而降低肿瘤干细胞的体外活性。因此，lincRNA-p21有望成为一种新型肿瘤生物标志物，在肿 瘤的早期诊断、治疗及预后评估等方面具有重要潜在价值。本文对lincRNA-p21在消化系统恶性肿瘤中作用的研究进展作一 综述。
- Full text:20191114.pdf
