An analysis on the surveillance results of safety of post-marketing immunization of varicella attenuated live vaccine in Henan Province
10.19485/j.cnki.issn1007-0931.2017.10.009
- VernacularTitle:水痘减毒活疫苗接种不良反应监测结果分析
- Author:
Lu-Bin SHI
1
;
Jian-Hui YANG
;
Yan-Fang JI
;
Jun LI
;
Yan YU
;
Ying YE
;
Yan-Yang ZHANG
Author Information
1. 河南省疾病预防控制中心免疫规划所
- Keywords:
Varicella attenuated live vaccine;
Preventive vaccination;
Adverse reactions
- From:
Journal of Preventive Medicine
2017;29(10):1009-1012,1016
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristics of adverse reactions for varicella attenuated live vaccine (VarV) in Henan Province from 2011 to 2016, in order to evaluate the immunization safety related to VarV. Methods The adverse reaction data and vaccination doses of VarV in Henan Province from 2011 to 2016 were collected through the China Information Management System for Immunization Programming. The descriptive methodology was used for data analysis. Results A total of 686 adverse reactions cases were reported in Henan Province from 2011 to 2016, and the average reported incidence rate was 16.89 per 100000 dose. The ratio of male to female was 1.14:1, and 80.61% cases occurred between 1 and 2 years old, and the reported incidence rate was 13.62 per 100000 dose. And 32.80% cases were reported from April to June, and the reported incidence rate was 5.54 per 100000 dose. The cases were mainly concentrated in Zhengzhou, Luoyang, Zhoukou and Xinyang. Most cases occurred after the first dose and within 1 d after vaccination. The main diagnoses of adverse reactions were fever, local swelling, indurations and transient anaphylactic disorders. The reported incidence rate of anaphylactic shock and fever convulsion were 0.37 per 100000 dose and 0.12 per 100000 dose respectively. All cases were recovered or got better. Conclusion The safety of VarV was good in Henan Province. However, the surveillance should focus on the anaphylactic shock and fever convulsion and other serious rare adverse reaction.
