An evaluation on immunization effect and the influencing factors after revaccination with 60 μg hepatitis B vaccine among non-response adults
- VernacularTitle:成人乙肝疫苗免疫无应答影响因素及60μg重组疫苗复种效果评价
- Author:
Sheng-Yu CHEN
1
;
Yun-Xian YU
;
Xue-Cai WANG
;
Xiao-Lian DONG
;
Zhi-Feng TANG
;
Ying-Feng CHEN
;
Xiao-Li WANG
Author Information
1. 浙江大学公共卫生学院
- Keywords:
Hepatitis B vaccine;
Non-responsiveness;
Immune effect;
Influencing factors
- From:
Journal of Preventive Medicine
2016;28(8):762-765
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore vaccine immune effects of 60μg hepatitis B on adults who have no response to hepatitis B vaccination.Methods A Total of 689 healthy adults who were HBsAg and anti -HBs negative were selected,and they were received 3 doses of hepatitis B vaccine at dosage 10 μg.Those with anti-HBs<10 IU/L detected after full series vaccination were given 1 dose of hepatitis B vaccine at dosage 60 μg.One month later,anti-HBs detection was conducted for them.Results The non -responsiveness rate was 17.71% after primary hepatitis B vaccination.The multivariate logistic regression analysis showed that risk factors for primary non-responsiveness were the history of surgical operation, immunization schedule and "anti-HBc alone".The anti-HBs positive rate was 95.5 1% in 89 re-vaccinated people, and the geometric mean titers of anti -HBs(GMT)was 585.39 IU/L.Conclusion Re -immunization of hepatitis B vaccine at dosage 60 μg has good immunogenicity in people who have no response to primary vaccination,and weight control may improve the effect of hepatitis B re-immunization.
