Establishment of quality standards for Xiangsu Weitong capsule

VernacularTitle:香苏胃痛胶囊质量标准研究
Author: Xin ZHAO ¹ ; Wei SHAO ; Peng ZHANG ; Zhiwei XU
Author Information

1. 原沈阳军区联勤部药品仪器检验所
Keywords: Xiangsu Weitong capsule; quality standards; TLC; HPLC
From: Journal of Pharmaceutical Practice 2018;36(3):265-269,288
CountryChina
Language:Chinese
Abstract: Objective To establish the quality standard for Xiangsu Weitong capsule.Methods Radixet rhizoma glycyr-rhizae,rhizoma corydalis,poria,rhizoma cyperi were identified by TLC and the contents of baicalin were determined by RP-HPLC.Chromatography conditions were Welchrom C18(4.6 mm×250 mm,5 μm)column.The mobile phase was acetonitrile-0.1% phosphoric acid(40:60).UV detection wavelength was set at 280 nm and the column temperature was 30 ℃ with the flow rate of 1.0 ml/min.Results The method of TLC had good resolution with clear spots and negative control showed no in-terference.The good linearity was obtained within the range of 1-80 μg/ml(r=0.999 9)for Tetrahydropalmatine hydrochloride and the average recovery was 99.1%(RSD= 1.28%,n= 6).Conclusion The method was simple,accurate and sensitive which could be applied in the quality control of Xiangsu Weitong capsule.