Research progress on correlation between ATP binding cassette transports and multidrug resistance of liver cancer
- VernacularTitle:ATP结合盒转运体与肝癌化疗耐药相关性的研究进展
- Author:
Wen-Bin LIU
1
;
Guang-Wen CAO
Author Information
1. 第二军医大学流行病学教研室
- Keywords:
liver cancer;
multidrug resistance;
ATP binding cassette transport;
verapamil
- From:
Shanghai Journal of Preventive Medicine
2017;29(4):249-252,287
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance (MDR) is a major problem in the current treatment of liver cancer.ATP binding cassette (ABC) transports induce drug effluxes in cancer cells, thus contributing to MDR.ABCB1 is a main subtype of ABC transports that mediates the MDR of liver cancer.The expression of ABCB1 is related to the stemness characteristics of liver cancer cells.The key molecules of a variety types of signaling pathways related to inflammation and cancer collaborate with one another and adjust the expression of ABC transports.Verapamil can reverse the MDR of liver cancer through inhibiting ABCB1.Further investigations of the relation between ABC transporters and the MDR in liver cancer can improve treatment strategy for cancer and reduce mortality.
