Research progress on the role and mechanism of Wnt signaling pathway in neuropathic pain
10.16438/j.0513-4870.2019-0624
- VernacularTitle:Wnt信号通路在神经病理性疼痛中的作用及机制研究进展
- Author:
Bi-rui WEN
1
;
Zhi-ling ZHANG
2
;
Nai-hong CHEN
1
Author Information
1. Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China; Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
neuropathic pain;
Wnt signaling pathway;
Wnt/β-catenin;
hyperpathia;
allodynia
- From:
Acta Pharmaceutica Sinica
2020;55(2):201-207
- CountryChina
- Language:Chinese
-
Abstract:
Neuropathic pain (NP), as a kind of chronic pain syndrome, seriously endangers the quality of life of patients, and the pathogenesis is complex, clinical treatment is limited, and it is easy to relapse. More and more reports have found that Wnt signaling pathway is closely related to the occurrence and development of neuropathic pain. Therefore, further study of the Wnt signaling pathway may provide useful ideas for exploring the pathogenesis of NP and discovering effective treatment methods. This article reviews the role and mechanism of Wnt signaling pathway in neuropathic pain.
