Progress in pharmacokinetics of oral transmucosal drug delivery systems
10.16438/j.0513-4870.2019-0598
- VernacularTitle:口腔黏膜给药系统的药物动力学研究进展
- Author:
Bing WANG
1
;
Hong-rui LIU
1
;
Fang CHEN
1
;
Ying-jun QUAN
2
;
Xiao-qiang XIANG
3
Author Information
1. National Pharmaceutical Engineering Research Center, China State Institute of Pharmaceutical Industry, Shanghai 201203, China
2. Fudan University Pudong Medical Center, Shanghai 201300, China
3. School of Pharmacy, Fudan University, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
oral mucosal absorption;
rug delivery system;
pharmacokinetics;
permeability;
osage form
- From:
Acta Pharmaceutica Sinica
2020;55(2):226-234
- CountryChina
- Language:Chinese
-
Abstract:
Oral transmucosal drug delivery can be defined as the administration of drug through the oral mucosa to achieve systemic effects. It has the advantages of high bioavailability and rapid drug response. In this review, we introduce the physiology of oral mucosa, and analyze the factors affecting the pharmacokinetic properties of oral transmucosal drug delivery in detail, such as physiological barriers, different administration sites, physicochemical properties of drugs, dosage forms, and formulation strategies. In addition, we describe the methods to evaluate the pharmacokinetic properties of this delivery systems, including in vitro permeability studies, buccal absorption studies, in vivo pharmacokinetic studies and physiologically based pharmacokinetics (PBPK) modeling, which provide methods and reference for the development of oral transmucosal drug delivery systems.
