Variability of Platelet Reactivity on Antiplatelet Therapy in Neurointervention Procedure
- Author:
Ho Jun YI
1
;
Gyojun HWANG
;
Byoung Hun LEE
Author Information
- Publication Type:Review
- Keywords: Aspirin; Clopidogrel; Platelet aggregation inhibitors; Platelet function tests
- MeSH: Aspirin; Blood Platelets; Embolization, Therapeutic; Fatal Outcome; Humans; Intracranial Aneurysm; Pathology; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents
- From:Journal of Korean Neurosurgical Society 2019;62(1):3-9
- CountryRepublic of Korea
- Language:English
- Abstract: As more intracranial aneurysms and other cerebrovascular pathologies are treated with neurointervention procedure, thromboembolic events that frequently lead to serious neurological deficit or fatal outcomes are increasing. In order to prevent the thromboembolic events, antiplatelet therapy is used in most procedures including coil embolization, stenting, and flow diversion. However, because of variable individual pharmacodynamics responses to antiplatelet drugs, especially clopidogrel, it is difficult for clinicians to select the adequate antiplatelet regimen and its optimal dose. This article reviews the neurointervention literature related to antiplatelet therapy and suggests a strategy for tailoring antiplatelet therapy in individual patients undergoing neurointervention based on the results of platelet function testing.
