Distribution of TT Virus Genotypes and Genogroups in 69 Healthy and 59 Hepatitis B Virus Infected Korean Individuals.
10.3343/kjlm.2007.27.4.257
- Author:
Han Sung KIM
1
;
Jae Seok KIM
;
Min Jung PARK
;
Wonkeun SONG
;
Hee Jung KANG
;
Kyu Man LEE
Author Information
1. Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea. kimhan@hallym.ac.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
TT virus (TTV);
Genotype;
Genogroup
- MeSH:
Adult;
Amino Acid Sequence;
DNA Virus Infections/diagnosis/*virology;
Female;
Genotype;
Hepatitis B/*complications/diagnosis;
Humans;
Korea;
Male;
Middle Aged;
Molecular Sequence Data;
Phylogeny;
Polymerase Chain Reaction/methods;
Torque teno virus/classification/*genetics
- From:The Korean Journal of Laboratory Medicine
2007;27(4):257-264
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: TT virus (TTV) infection is highly prevalent in general population and patients with hepatitis B virus (HBV) infection. The aim of the present study was to determine the distribution of the genotypes and genogroups of TTV in healthy and HBV-infected individuals in Korea. METHODS: Distribution of TTV genotypes and genogroups was investigated in the serum samples of 69 healthy and 59 HBV-infected individuals. PCR products of N22 region were genotyped by sequence analysis. TTV genogroups were determined by 5 different genogroup-specific PCR assays. RESULTS: Among the 20 sequenced isolates, 9 (45%) were genotype 2, 8 (40%) were genotype 1, 2 (10%) were genotype 3, and 1 (5%) was genotype 4. TTV genogroup 4 was found most frequently (52/128), followed by genogroup 3 (42/128), genogroup 1 (35/128), genogroup 5 (32/128), and genogroup 2 (1/128). Mixed infections with different genogroups were frequent. CONCLUSIONS: TTV genotype 2 and 1 are predominant genotypes. TTV genotype 3 was detected for the first time in Korea. TTV genogroups 4 and 3 were predominant genogroups. No significant difference was observed in the distribution of TTV genogroups between healthy and HBV-infected individuals.
