Occlusive Myocardial Infarction: Cardiac CT Perfusion in a Rat Model.
10.3348/jkrs.2007.56.3.233
- Author:
Hyung Woo OH
1
;
Dong Hun KIM
;
Joo Nam BYUN
;
Young Sook KIM
Author Information
1. Department of Radiology, Chosun University, College of Medicine, Korea. kdhoon@chosun.ac.kr
- Publication Type:Original Article
- Keywords:
Heart, CT;
Myocardium, infarction
- MeSH:
Animals;
Arteries;
Coronary Vessels;
Follow-Up Studies;
Heart;
Models, Animal*;
Myocardial Infarction*;
Myocardium;
Perfusion Imaging;
Perfusion*;
Rats*;
Thoracotomy;
Tomography, X-Ray Computed
- From:Journal of the Korean Radiological Society
2007;56(3):233-238
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To test whether cardiac multidetector CT (MDCT) perfusion imaging can accurately delineate an irreversibly damaged myocardium in animals with an occlusive myocardial infarction. MATERIALS AND METHODS: In 16 rats, the left anterior descending coronary arteries were ligated distal to its first diagonal artery after a thoracotomy. Thirty minutes after the procedure, 16-slice MDCT (Sensation 16, Siemens, Erlangen, Germany) was performed and delayed images were obtained up to 5 minutes after injecting the contrast agent (0.2 mL/100g, 0.5 mL/sec). Ten rats were re-examined one week later. After CT scanning, the rats were sacrificed and their hearts were extirpated for 2,3,5-triphenyltetrazolium chloride (TTC) histochemical staining. The stained slices were compared with the CT images. The CT number (HU) of the infarct and non-infarct areas were estimated from the contrast ratio (CR). RESULTS: The CT attenuation in the infarct area was significantly lower than that in the normal myocardium. Quantitative analysis of the CT attenuation revealed a significant difference in the CR and CT attenuation of the infarct and reference areas (0.48+/-0.12 vs 0.64+/-0.13, p<0.05, 163+/-46 HU vs 216+/-56 HU, p<0.05). However, there were no significant differences in the CT numbers between the infarct and non-infarct areas on the one-week follow-up. CONCLUSION: A perfusion defect on MDCT indicates the myocardial damage in an animal model with occlusive myocardial infarction.
