Adjuvant therapy of moxibustion combined with formula for peritoneal effusion of ovarian malignant tumors.
10.13703/j.0255-2930.2019.12.010
- Author:
Lin XU
1
;
Rui LI
1
;
Qiao-Li ZHANG
1
Author Information
1. Department of Acupuncture and Moxibustion for Minimally Invasive Cancer, Third Affiliated Hospital of Beijing University of CM, Beijing 100029, China.
- Publication Type:Journal Article
- Keywords:
Wenyang Lishui formula;
immune function;
moxibustion;
peritoneal effusion of malignant ovarian tumors
- MeSH:
Acupuncture Points;
Ascitic Fluid;
Humans;
Moxibustion;
Neoplasms;
Quality of Life
- From:
Chinese Acupuncture & Moxibustion
2019;39(12):1294-1298
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy of adjuvant therapy of moxibustion combined with formula for peritoneal effusion of ovarian malignant tumors.
METHODS:Sixty patients with peritoneal effusion of ovarian malignant tumors were randomly divided into an observation group and a control group, 30 cases in each group. The patients in the control group were treated with intravenous infusion of paclitaxel liposome at the first day and cisplatin at the 2nd to 4th day, 21 days as a course of treatment, and 4 courses were given. Based on the treatment of the control group, the patients in the observation group were treated by moxibustion combined with formula. Moxibustion was applied at Mingmen (GV 4), Pishu (BL 20), Shenshu (BL 23), Shenque (CV 8), Guanyuan (CV 4), Zigong (EX-CA 1), Zhongwan (CV 12), Shuifen (CV 9), Qihai (CV 6) and Zhongji (CV 3), each acupoint for 30 min, once a day for 12 weeks. formula was taken twice orally, one dose a day, 2 weeks as a course of treatment, and 6 courses were given. The levels of , , and / in peripheral blood were measured before and after 12-week treatment in the two groups. The changes of peritoneal effusion volume and Karnofsky performance status scale (KPS) score before and after treatment were compared between the two groups, and the clinical efficacy of the two groups was evaluated.
RESULTS:The symptom improvement rate was 96.7% (29/30) and overall effective rate was 86.7% (26/30) in the observation group, which were significantly superior to those in the control group [80.0% (24/30) and 56.7% (17/30), <0.05]. After treatment, the levels of , and / in peripheral blood were significantly increased in the observation group (<0.01), there was no significant difference in the control group before and after treatment (>0.05), and the increase in the observation group was significantly higher than that in the control group (<0.05). After treatment, the volume of peritoneal effusion in the two groups was decreased (<0.01), and the reduced volume in the observation group was higher than that in the control group (<0.05). After treatment, KPS scores were increased significantly in both two groups (<0.01), and the increase in the observation group was higher than that in the control group (<0.05). The incidence rate of adverse reactions in the observation group was lower than that in the control group [23.3% (7/30) vs 53.3% (16/30), <0.05].
CONCLUSION:Moxibustion combined with formula could effectively improve the immune function, reduce the volume of peritoneal effusion, improve the symptom improvement rate, overall effective rate and the quality of life, and reduce the incidence of adverse reactions in chemotherapy of patients with peritoneal effusion of ovarian malignant tumors.
