Research Advances on the Biological Characteristics of Hematological Malignant Cells Immunologically Regulated by Exosome--Review.
10.7534/j.issn.1009-2137.2020.01.057
- Author:
Xiao-Yan JIANG
1
;
Ya-Zhi YANG
1
;
Xian-Liang HU
1
;
Hui-Jun CHEN
1
;
Jian LI
2
Author Information
1. Key Laboratory of Hematology , The Second Affiliated Hospital of Nanchang University,Nanchang 330006，Jiangxi Province，China,Medical Department of Nanchang University Postgraduate School, Nanchang 330006，Jiangxi Province，China.
2. Key Laboratory of Hematology , The Second Affiliated Hospital of Nanchang University,Nanchang 330006，Jiangxi Province，China,E-mail:ndefy03048@ncu.edu.cn.
- Publication Type:Journal Article
- From:
Journal of Experimental Hematology
2020;28(1):339-342
- CountryChina
- Language:Chinese
-
Abstract:
Abstract The minimal residual disease (MRD) is the origin element that caused the relapse and drug resistance of hematological malignancies, the immune cells play a great role to clear MRD. A variety of immune cells have anti-tumor effects. However, tumor cells antagonize anti-tumor effects by reprogramming of constituents associated with tumor environment. Many different cell types, including immune cells, mesenchymal cells and tumor cells in tumor microenvironment release exosomes. The latest researches indicate that "cargo" and surface ligands carried by exosomes secreted by hematological malignant cells not only can affect the function of natural killer cell (migration, activation, proliferation, secretion and NKG2D expression), macrophage (migration and secretion) and dendritic cell (maturation and presentation), but also regulate the expression of PD-L1 and CCR2, CCL2 secretion and transformation of monocytes. The altered function of immune cells will eventually have effect on the progression of hematological malignancies.
