Therapeutic Response and Prognosis of Adult Acute Myeloid Leukemia with Chromosome Karyotype Abnormalities.
10.7534/j.issn.1009-2137.2019.06.002
- Author:
Yue CHEN
1
;
Shan-Dong TAO
1
;
Yu-Ye SHI
1
;
Li-Xiao SONG
1
;
Yuan DENG
1
;
Lan-Lan LING
1
;
Bang-He DING
1
;
Kan-Kan CHEN
1
;
Zheng-Mei HE
1
;
Chun-Ling WANG
1
;
Liang YU
2
,
3
Author Information
1. Department of Hematology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China;Key Laboratory of Hematology of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
2. Department of Hematology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China;Key Laboratory of Hematology of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China,E-mail: yuliangha@
3. com.
- Publication Type:Journal Article
- MeSH:
Adult;
Chromosome Aberrations;
Humans;
Karyotype;
Karyotyping;
Leukemia, Myeloid, Acute;
Prognosis;
Retrospective Studies
- From:
Journal of Experimental Hematology
2019;27(6):1717-1721
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the efficacy and prognosis of acute myeloid leukemia (AML) patients with chromosome karyotype abnormalities.
METHODS:The clinical features and treatment responses of 91 patients with AML were collected and analyzed retrospectively. The efficacy and survival rate of the AML patients with normal and abnormal chromosome karyotype were compared.
RESULTS:Chromosome translocations and monosomal karyotypes were the main heterogeneity of AML. There was no significant difference in complete remission rate and overall response rate between the normal and abnormal karyotype groups, but the recurrence rate was higher in abnormal karyotype group. There was no significant difference in response of AML patients received the standard "3+7 regimen" and pre-excitation chemotherapy in the treatment of normal and abnormal karyotype groups. The relapse free survival time (RFS) was longer in the normal karyotype group, but there was no significant difference in overall survival time (OS).
CONCLUSION:The abnormal karyotype of AML is an independent prognostic factor, monosomal karyotype shows a poor prognosis, and the recurrence rate in AML patients with monosomal karyotype is higher.
