Highly oxygenous trichilin-type limonoids from Trichilia sinensis.
10.1016/S1875-5364(19)30112-8
- Author:
Fa-Liang AN
1
;
Yong YIN
1
;
Jun LUO
2
;
Ling-Yi KONG
3
,
4
Author Information
1. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
2. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: luojun@cpu.edu.cn.
3. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpu_lykong@
4. com.
- Publication Type:Journal Article
- Keywords:
Cytotoxic activity;
Trichilia sinensis;
Trichilin-type limonoids
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(12):912-917
- CountryChina
- Language:English
-
Abstract:
Six new trichilin-type limonoids (1-6) with C-19/29 lactol or acetal bridge and a new ring intact limonoid (7) were isolated from the desiccative ripe fruits of Trichilia sinensis. Their structures were determined by extensive spectroscopic methods including H NMR, C NMR, HSQC, HMBC, ROESY experiments as well as HRESI-MS data. All isolated compounds were evaluated for toxicities against human pulmonary carcinoma A549 and Hela cell lines by sulforhodamine B (SRB) method. Compound 7 showed weak inhibitory activity in Hela cell line at 40 μmol·L.
