Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum.
10.1016/S1875-5364(19)30119-0
- Author:
Guang-Hui HUANG
1
;
Chun LEI
2
;
Ke-Xin ZHU
3
;
Jing-Ya LI
3
;
Jia LI
3
;
Ai-Jun HOU
4
Author Information
1. School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, China.
2. School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, China. Electronic address: chunlei@fudan.edu.cn.
3. National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
4. School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, China. Electronic address: ajhou@shmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Meroterpenoid enantiomers;
Protein tyrosine phosphatase 1B;
Rhododendron fastigiatum
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(12):963-969
- CountryChina
- Language:English
-
Abstract:
Five pairs of optically pure meroterpenoid enantiomers (1a/1b-5a/5b) and two known compounds (6 and 7) were isolated from Rhododendron fastigiatum. Compounds 1a/1b-5a/5b were resolved from naturally scalemic mixtures by chiral HPLC. Their structures were elucidated by spectroscopic methods, X-ray crystallographic experiments, and ECD analyses. Compounds 1a/1b, 2a/2b, 3b, 4a/4b, and 5a/5b were new meroterpenoids with different polycyclic systems. Two enantiomeric pairs (2a/2b and 3a/3b), 6, and 7 exhibited inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) in vitro.
