Expression and significance of Survivin and Bcl-2 in nasal aquamous cell carcinoma
10.13201/j.issn.1001-1781.2016.07.005
- Author:
Jin Hui LIANG
1
;
Hailin LUO
1
;
Fang LONG
1
;
Li LI
1
;
Huanglang HUANG
1
;
Mei HUANG
1
;
Xiang ZHANG
1
;
Weidong MAO
2
Author Information
1. Department of Otolaryngology Head and Neck Surgery,Hanzhong Central Hospital,Hanzhong,723000,China
2. Department of Pathology,Hanzhong Central Hospital
- Publication Type:Journal Article
- Keywords:
nasal cavity;
paranasal sinuses;
carcinoma;
squamous cell;
Survivin;
Bcl-2
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2016;30(7):529-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and it's clinical significance of Survivin and Bcl-2 in nasal squamous cell carcinoma (SNSCC). Method:The immunohistochemical Envision two step method was used to measure the expression of Survivin and Bcl-2 in 35 cases of SNSCC, 20 cases of normal inferior concha tissues. Result:The expression of Survivin in SNSCC was 88.6%, significantly higher than the normal inferior turbinate mucosal tissue expression of 0% (P<0.01). The expression of Bcl-2 in SNSCC was 71.4%, significantly higher than the normal inferior turbinate mucosal tissue expression of 25% (P<0.01). Expression of Bcl-2 was significantly higher in SNSCC than in normal tissue. The expression of Survivin was positively correlated with Bcl-2 expression (P<0.01). The higher the grade of tumor, the lower expressions of Survivin and Bcl-2. Conclusion:Survivin and Bcl-2 may play an promoting role in the development and progression process of SNSCC. Survivin may become a target spot of SNSCC gene therapy.
