Trichilin-type limonoids isolated from the fruits of Trichilia connaroides
10.16438/j.0513-4870.2019-0736
- VernacularTitle:鹧鸪花果实trichilin-type柠檬苦素化学成分研究
- Author:
Fa-liang AN
1
;
Jun LUO
1
;
Ling-yi KONG
1
Author Information
1. Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
- Publication Type:Research Article
- Keywords:
italic>Trichilia connaroides;
limonoids;
cytotoxicity
- From:
Acta Pharmaceutica Sinica
2020;55(1):106-109
- CountryChina
- Language:Chinese
-
Abstract:
Two new trichilin-type limonoids were isolated from the fruits of Trichilia connaroides along with two known limonoids, 3α-deacetylamoorastatin (3) and mesendanins K (4). Their planar structure and relative configuration were elucidated by comprehensive analyses of HR-ESI-MS, 1H NMR, 13C NMR, HSQC, HMBC and ROESY data. An antitumor activity assay showed that compounds 1, 2 and known compound 4 had weak cytotoxicity against a human cervical cancer cell line (HeLa).
