Research advances in understanding the senescence-associated secretory phenotype and relevant drugs
10.16438/j.0513-4870.2019-0603
- VernacularTitle:衰老相关分泌表型的作用机制及相关药物研究进展
- Author:
Wen-ge ZHENG
1
;
Xue-mei QIN
2
;
Li GAO
2
;
Guan-hua DU
3
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
2. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
3. Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
senescence-associated secretory phenotype;
senescent cell;
pathway;
rug
- From:
Acta Pharmaceutica Sinica
2020;55(1):8-14
- CountryChina
- Language:Chinese
-
Abstract:
The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of a series of cytokines such as pro-inflammatory factors, chemokines and proteases, and is a key feature of senescent cells. SASP is a double-edged sword that can resist a harmful environment in normal cells, but with the decline of body function, the massive secretion of cytokines, chemokines and proteases accelerates aging while inducing inflammation, leading to the development of various aging-related diseases. This article reviews the composition and physiological functions of SASP, the changes in SASP during aging, the regulatory pathways associated with SASP, and the anti-aging drugs that regulate SASP. This article aims to present a more comprehensive understanding of SASP and lay the foundation for SASP-based anti-aging research and the discovery of new targets for anti-SASP drugs.
