Concentration-dependent effects of nitric oxide on tumors and chemosensitivity
10.16438/j.0513-4870.2019-0491
- VernacularTitle:一氧化氮对肿瘤作用的浓度依赖作用和化疗增敏机制
- Author:
Hui-lan LI
1
;
Yi JIN
1
;
Yuan-ting MAO
1
;
Guo-liang XU
2
;
Yuan-ying FANG
1
Author Information
1. National Engineering Research Center for the Manufacturing Technology of Solid Chinese Medicine
2. Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of TCM, Nanchang 330004, China
- Publication Type:Research Article
- Keywords:
nitric oxide;
tumor;
concentration;
mechanism;
chemotherapy sensitization
- From:
Acta Pharmaceutica Sinica
2020;55(1):33-37
- CountryChina
- Language:Chinese
-
Abstract:
The resistance and dose limitation of tumors is a serious obstacle to cytotoxic drug therapy in the field of medical oncology. Nitric oxide (NO) is a powerful adjuvant for tumor hypersensitivity for traditional chemotherapy and radiation therapy. The concentration of NO plays an important role in affecting its anti-tumor effect. This review summarizes the mechanism of concentration-dependent effects of NO on tumor cells and the mechanism of chemotherapy sensitization. It provides evidence for rational use of NO to exert anti-tumor effects, and overcoming multidrug resistance and anti-tumor drug development.
