Association of estrogen receptor α gene polymorphisms with hepatitis B cirrhosis
10.3969/j.issn.1001-5256.2020.01.044
- VernacularTitle:雌激素受体α基因多态性与乙型肝炎肝硬化的关系
- Author:
Na CHENG
1
;
Jing YANG
Author Information
1. Department of Infectious Diseases, Guizhou Medical University, Guiyang 550004, China
- Publication Type:Research Article
- Keywords:
estrogen receptor alpha;
polymorphism, genetic;
hepatitis B;
liver cirrhosis
- From:
Journal of Clinical Hepatology
2020;36(1):186-189
- CountryChina
- Language:Chinese
-
Abstract:
At present, hepatitis B cirrhosis still has a major impact on public health and national development. The development and progression of hepatitis B cirrhosis is associated with estrogen. Estrogen acts by binding to estrogen receptors, and the expression and functional status of estrogen receptors are affected by estrogen receptor gene polymorphisms. This article mainly introduces the structure and biological characteristics of estrogen and estrogen receptor α gene and their association with the pathogenesis of hepatitis B cirrhosis, and it is pointed out that the abnormal expression of estrogen may be associated with the development and progression of hepatitis B cirrhosis. However, due to the differences in genetic loci, environment, and location between studies, the results of the association of estrogen receptor α gene polymorphisms with hepatitis B cirrhosis may not be completely consistent.
