Urinary tract infection and non-ruptured acute appendicitis association: Uro-pathogens findings

Al Fraijat, B; Al-Tawarah, NM; Khlaifat, AM; Qaralleh, H; Khleifat, KM; AM; Al-Zereini, W; Al-limoun, MO

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Urinary tract infection and non-ruptured acute appendicitis association: Uro-pathogens findings

Author: Al Fraijat, B. ¹ ; Al-Tawarah, N.M. ² ; Khlaifat, A.M. ³ ; Qaralleh, H. ² ; Khleifat, K.M. ¹ ; A.M. ² ; Al-Zereini, W. ¹ ; Al-limoun, M.O. ¹
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1. Department of Biology, Mutah University, Mutah, Karak, 61710, Jordan
2. Department of Medical Laboratory Sciences, Mutah University, Mutah, Karak, 61710, Jordan
3. Department of Laboratory Medical Sciences, Princess Aisha Bent Al-Hussein, Faculty of Nursing and Health Sciences, Al Hussein bin Talal University, Jordan
Publication Type:Journal Article
From:Tropical Biomedicine 2019;36(3):620-629
CountryMalaysia
Language:English
Abstract: Urinary Tract Infections (UTIs) consider as the most common infections worldwide, with higher risk in patients experienced Acute Appendicitis (AA). The purpose of this study was, to investigate the bacterial profile of UTIs in patients with non-ruptured AA postsurgically, and to assess age- and gender-related links of all AA cases in Karak region, Jordan. Urine samples obtained from 46 cases (32 male and 14 female) aged between 16-70 years were diagnosed as non-ruptured AA, following with isolation and characterization of isolated bacteria. Out of 46 AA cases, uropathogens isolated from 25 (54.3%) UTI cases. Out of these isolates; 42 (73.7%) were gram-negative isolates and 15 (26.3%) were gram-positive bacteria. The percentage of isolates were E. coli (26.3%), Enterobacter species (21%), Enterococcus faecalis and Klebsiella pneumoniea (10.5%) for each, Streptococcus saprophytics and Pseudomonas aeruginosa (7%) for each, Yersinia spp. and S. milleri (8.8%). Out of UTI cases, 20 cases (80%) possessed mixed culture, each of them had at least one of Enterobacterial species. i.e. Enterobacter spp. or E. coli or both. More precisely, out of all these positivecases, 2 cases had pure gram positive-bacterial infection (8%), while pure gram negative bacterial infection comprised 48% of them and the rest (44%) were mixed (gram-negative and gram-positive) bacterial infection. Moreover, study revealed a high prevalence rate of AA cases 24 (52.2%) in the ages of 16-22 years, then declining the rate with increasing the age, reaching the lowest rate (4.3%) in ages of 60-70. In addition to age factor, the males significantly more susceptible to AA cases than females by 2.2-fold. Antibiotic sensitivity test revealed high resistance capability of E. coli to the most used antibiotics except for nitrofurantoin. Bacterial isolates showing sensitivity against ciprofloxacin, trimethoprim/sulfamethoxazole, amoxicillin-Clavulanic acid and nitrofurantoin, with a superiority for the first two. Results demonstrate high prevalence rate of UTIs in patients with AA. For avoiding, the needless use of antibiotics through sticking to our accountability as healthcare provisioner to pursuit the antimicrobial management.
Full text:8.2019my1048.pdf