A new furocoumarin from the stems of Clausena lansium
- VernacularTitle:黄皮中的新呋喃香豆素
- Author:
Xing-yan SUN
1
;
Jie MA
1
;
Chuang-jun LI
1
;
Ji-wu HUANG
1
;
Nan WANG
1
;
Cang-jie SHEN
1
;
Dong-ming ZHANG
1
Author Information
- Publication Type:Research Article
- Keywords:
italic>Clausena
lansium ; chemical constituents; furocoumarin; cytotoxicity - From: Acta Pharmaceutica Sinica 2019;54(12):2282-2285
- CountryChina
- Language:Chinese
-
Abstract:
One undescribed and two known furocoumarins were isolated from the stems of the
Clausena lansium through a series of isolation and purification approaches including HPD-100 macroporous resin column, silica gel, reverse phase C18 and so on. Their structures were determined to be 8-[(2S ,3S ,6E )-2,3-epoxy-3,7-dimethyl-oct-6-enyloxy] psoralen (1 ), 8-(7',8'-epoxygeranyloxy) psoralen (2 ) and 8-[(2E )-6-oxo-3,7-dimethyloct-2-enyloxy] psoralen (3 ) by spectroscopic methods. Compound1 is a new furocoumarin. Compound2 showed cytotoxicity to H460 (IC50 = 43.94 μmol·L-1) and compound3 showed cytotoxicity to HeLa (33.76 μmol·L-1) through the cytotoxic tests against five human cancer cell lines (H460, H7402, HCT-8, HeLa and MCF-7) for all compounds.
