Quality evaluation and toxicity assay for injectable traditional Chinese medicine using Microtox technology
10.16438/j.0513-4870.2019-0503
- VernacularTitle:基于微小毒性检测的中药注射剂质量波动及安全风险预警研究进展
- Author:
Liang-chun YAN
1
;
Hua HUA
1
;
Xi LUO
1
;
Jun-ning ZHAO
1
Author Information
1. Sichuan Academy of Chinese Medicine Sciences, Sichuan Center for Translational Medicine of Traditional Chinese Medicine, Key Laboratory of Biological Evaluation of Traditional Chinese Medicine Quality of the State Administration of Traditional Chinese Medicine, Sichuan Engineering Technology Research Center of Genuine Regional Drug, Sichuan Provincial Key Laboratory of Quality Evaluation and New Drug Creation of Traditional Chinese Medicine, Laboratory for Rapid Detection of Toxicity of Traditional Chinese Medicine in Sichuan Provincial Administration of Chinese Medicine, Chengdu 610041, China
- Publication Type:Research Article
- Keywords:
traditional Chinese medicine injection;
microtoxicity;
Microtox technology;
quality fluctuation;
risk early warning
- From:
Acta Pharmaceutica Sinica
2019;54(12):2189-2194
- CountryChina
- Language:Chinese
-
Abstract:
Injectable traditional Chinese medicine often contains multiple components including undefined toxic substances, can have high variability between batches, with undefined mechanisms of action. It is urgent to improve the quality and consistency and reduce the toxicity risk of traditional Chinese medicine. The Microtox technology is a simple, rapid method for the detection of toxic substances in the environment that uses non-pathogenic luminescent bacteria as an indicator, and the change in luminosity as an index. Using this bioassay we have systematically applied Microtox technology for the detection of microtoxicity in injectable traditional Chinese medicine. As a new method of bioactivity characterization, Microtox technology is expected to be used in the detection of quality fluctuations and toxicity risks at an early stage in the preparation of injectable traditional Chinese medicines and to improve the quality of injectable traditional Chinese medicine.
