Post-translational modifications of proteins and cancer immunotherapy
10.16438/j.0513-4870.2019-0695
- VernacularTitle:蛋白翻译后修饰与肿瘤免疫治疗
- Author:
Jing JIN
1
;
Ming JI
1
;
Xiao-guang CHEN
1
Author Information
1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
post-translational modifications of proteins;
cancer;
cancer microenvironment;
cancer immunotherapy
- From:
Acta Pharmaceutica Sinica
2019;54(10):1711-1717
- CountryChina
- Language:Chinese
-
Abstract:
Post-translational modifications (PTMs) of proteins is an important mode of protein function regulation, which is essential for the structure and function of proteins under physiological and pathological conditions, and the types of modifications is wide. Cancer immunotherapy refers to an effective method for cancer treatment by activating or normalizing disabled immune cells. In recent years, researchers have found that many types of PTM are involved in the process of proliferation, activation and metabolic reprogramming of immune cells in cancer microenvironment, and may affect the efficacy of cancer immunotherapy. Therefore, this article reviews the effects of several different PTMs on immune cells in cancer microenvironment, and aims to provide new ideas for cancer immunotherapy.
