Research progress of carnitine palmitoyltransferase 1in tumor immunotherapy
10.16438/j.0513-4870.2019-0689
- VernacularTitle:肉毒碱棕榈酰转移酶1对肿瘤发生与免疫系统调控研究进展
- Author:
Ming-yi ZHANG
1
;
Ting-ting DU
1
;
Ming JI
1
;
Xiao-guang CHEN
1
Author Information
1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
carnitine palmitoyltransferase 1;
fatty acid β-oxidation;
tumor;
immune system;
metabolism
- From:
Acta Pharmaceutica Sinica
2019;54(10):1824-1830
- CountryChina
- Language:Chinese
-
Abstract:
Carnitine palmitoyltransferase 1 (CPT1) is a fatty acid β-oxidative rate-limiting enzyme of fatty acid β-oxidation (FAO) present in the outer membrane of mitochondria, which is closely related to metabolic diseases and tumors. Numerous studies have shown that various subtypes of CPT1 are abnormally expressed in cancer cells and play an important role in resistance to metabolic stress. With the development of tumor immunotherapy, its role in immune cells and organs has also attracted attention. This article aims to review the biological functions of CPT1 and the role of different subtypes in tumor metabolism and immune regulation, and the research progress of its inhibitors, providing new ideas for cancer treatment.
