Research progress of tumor immune and tumor metabolic drug targets
10.16438/j.0513-4870.2019-0581
- VernacularTitle:肿瘤免疫和代谢药物靶点研究进展
- Author:
Jin-yi LIU
1
;
Li-wen REN
1
;
Sha LI
1
;
Qin TANG
1
;
Wan LI
1
;
Xiang-jin ZHENG
1
;
Jin-hua WANG
1
;
Guan-hua DU
1
Author Information
1. Beijing Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
tumor microenvironment;
tumor immunology;
tumor metabolism;
rug target
- From:
Acta Pharmaceutica Sinica
2019;54(10):1718-1727
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of tumors are closely related to the tumor microenvironment. Among them, tumor immune microenvironment and tumor metabolic microenvironment play important roles in tumor. Tumor immunotherapy is a way to kill tumor cells by activating the body's immune system. Tumor immunotherapy has shown good therapeutic effects in a variety of solid tumors. In recent years, significant progress has been made in tumor immunotherapy. The Warburg effect indicates that tumor cells use aerobic glycolysis to acquire energy. In the tumor, the energy metabolism pathway is abnormal, and the tumor microenvironment can induce the reprogramming of tumor cell metabolism. Therefore, targeting tumor metabolism is also of great significance for tumor treatment. In this paper, we reviewed the research progress of drug targets related to tumor immunology and tumor metabolism in recent years, as well as the progress of drug development.
