Mechanisms of metabolite-triggered oncogenic signaling in cancer
10.16438/j.0513-4870.2019-0543
- VernacularTitle:代谢产物调控肿瘤信号通路的分子机制研究进展
- Author:
Xiao-min WANG
1
;
Min HUANG
1
Author Information
1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100009, China
- Publication Type:Research Article
- Keywords:
metabolism remodeling;
neoplasm;
metabolite;
signal transduction;
tumor microenvironment;
gastrointestinal microbiome
- From:
Acta Pharmaceutica Sinica
2019;54(10):1755-1770
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic remodeling, a well-recognized hallmark of cancer, provides biomass and energy to support the growing demand of unrestricted growth of cancer cells. In addition to metabolic supplies, the altered cell metabolism often results in the intracellular accumulation of particular metabolites. Recently, it is increasingly revealed these metabolites may exhibit metabolism-independent roles as signaling molecules, which triggers oncogenic signaling via various mechanisms including competitive inhibition, protein post-translational modifications and direct protein binding. These insights provide a new perspective of metabolic remodeling in cancer progression. This review summarized the recent advancement in the understanding of metabolites as signaling molecules independent rewriting of metabolic pathways. By summarizing these progresses, this review hopes to provide a better understanding of tumor metabolic disturbance and to contribute to the discovery of novel potential therapeutic targets.
