Research progress of circular RNA in regulating vascular endothelial dysfunction
10.16438/j.0513-4870.2018-0790
- VernacularTitle:Circular RNA调控血管内皮功能失调研究进展
- Author:
Yi-xiu ZHAO
1
;
Xue LIU
1
;
Yan ZHANG
1
Author Information
1. Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, China
- Publication Type:Research Article
- Keywords:
noncoding RNA;
vascular endothelium;
atherosclerosis;
apoptosis;
hyperglycemia;
hypoxia
- From:
Acta Pharmaceutica Sinica
2019;54(2):228-234
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis refers to vascular pathological changes in which vascular lumen was narrowed or blocked by cholesterol or fat existed in vascular endothelium, which could induce serious cardiovascular events. The pathogenesis of atherosclerosis is complicated extremely. Vascular endothelial dysfunction initiated the plague formation and deterioration, which determined the prognosis of atherosclerosis. Circular RNA (circRNA) is a special endogenous non-coding RNA, which has become a research hotpot in the field of non-coding RNA. This review aims to bring together the recent research on the pathogenesis and pathological process of endothelial dysfunction, and the regulative effect of circRNA on it. Our article will provide new targets and new ideas for the research and development of anti-atherosclerosis drugs.
