Research advancement in the construction and applications of microfluidic devices for in vitro blood-brain barrier research
10.16438/j.0513-4870.2018-0773
- VernacularTitle:基于微流控芯片的体外血脑屏障模型构建与应用研究进展
- Author:
Ying CAI
1
;
Yang CHEN
2
;
Wen-ting ZHOU
2
;
Yue-hua LIAO
3
;
Zhan-ying HONG
2
;
Yi-feng CHAI
2
Author Information
1. School of Pharmacy, Second Military Medical University, Shanghai 200433, China; School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China
3. Shanghai University of Medicine & Health Sciences, Shanghai 201318, China
- Publication Type:Research Article
- Keywords:
blood-brain barrier;
microfluidic chip;
model establishment;
characterization;
application
- From:
Acta Pharmaceutica Sinica
2019;54(2):269-280
- CountryChina
- Language:Chinese
-
Abstract:
The blood-brain barrier (BBB) not only maintains the stability of the environment within the central nervous system by controlling the transport of substances on both sides of the blood and brain, but also plays an important role in the R&D of new drugs for neurological disorders. The establishment of an in vitro high-fidelity model to study BBB function is imperative for assessing barrier permeability of drugs and xenobiotics. However, the complexity of the BBB structure makes it difficult to replicate with an in vitro model. Compared to the traditional in vitro BBB model, the BBB-on-chip provides certain advantages in miniaturizing the system, reducing the amount of cells and medium required, and allowing simultaneously induction of shear stress. We review here the BBB-on-chip models from their establishment and characterization to applications in research of neuroinflammation, brain tumor and drug evaluation.
