Antitumor status analysis on the co-delivery systems regarding the active ingredients of Chinese herbs combined with chemotherapeutic drugs
10.16438/j.0513-4870.2018-0659
- VernacularTitle:中药活性成分协同化疗药物的纳米共载体系联合抗肿瘤现状分析
- Author:
Jin-feng SHI
1
;
Jie LI
1
;
Xiao-qin YANG
1
;
Yue ZHANG
1
;
Shi-cai YANG
1
;
Yao-yao LUO
1
;
Jin-ming ZHANG
1
;
Chao-mei FU
1
Author Information
1. Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province—State Key Laboratory Breeding Base Co-founded by Sichuan Province and MOST, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
- Publication Type:Research Article
- Keywords:
nanocarrier;
co-delivery;
Chinese herb;
active ingredient;
chemotherapy drug
- From:
Acta Pharmaceutica Sinica
2019;54(2):258-268
- CountryChina
- Language:Chinese
-
Abstract:
Anti-tumor intervention using a combination of drugs shows unique advantages in research and clinical practice. Active ingredients of Chinese herbal medicines can offer many advantages, such as high efficiency, low toxicity, wide effect and multiple targets. At present, the combination active ingredients of Chinese herbal and chemotherapy drugs have attracted increased attention. Nano-drug delivery system provides a good carrier platform for anti-tumor drugs. Nano-carrier-mediated drug combination is a promising strategy. In this paper, we review the mechanisms of the anti-tumor effects of active ingredients of traditional Chinese medicine combined with chemotherapeutic drugs and consider the advantages of drug-loaded nanoparticles, the types and characteristics of carriers. The aim is to provide a reference for the research of effective regimen for anti-tumor therapy.
