Bacterial biofilms: characteristics and combat strategies
10.16438/j.0513-4870.2018-0892
- VernacularTitle:细菌生物膜的特征及抗细菌生物膜策略
- Author:
Xiao-nan CHEN
1
;
Yuan-na SHEN
1
;
Peng-yu LI
1
;
Yi-qing ZOU
1
;
Hai-yan HU
1
Author Information
1. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
- Publication Type:REVIEWS
- Keywords:
biofilm;
drug resistance;
extracellular polymeric substance;
adjuvant;
drug delivery system;
molecular imprinted polymer
- From:
Acta Pharmaceutica Sinica
2018;53(12):2040-2049
- CountryChina
- Language:Chinese
-
Abstract:
Eighty percent of bacterial infections are related to the formation of bacterial biofilm. Compared with planktonic bacteria, bacterial biofilm is 10-1 000 times more resistant to antibiotics, which is the main cause of current bacterial drug resistance. A comprehensive understanding of the characteristics and resistance mechanisms of bacteria biofilm will help us treat the stubborn infections caused by the bacterial biofilm better and solve the problem of bacterial drug resistance. In this review, the composition and quorum sensing of bacterial biofilm, two major patterns of biofilm formation and drug resistance mechanisms were presented. Furthermore, representative compounds with anti-biofilm activity and compounds synergistic with antibiotics in anti-biofilm actions were introduced. Nano drug delivery strategies used for anti-biofilm in recent years as well as a novel drug delivery system-molecularly imprinted polymer was also introduced.
