Recent advances in the research on pharmacological actions and quantitative analyses of naphthoquinones in Chinese medicinal herb “Zicao”
10.16438/j.0513-4870.2018-0583
- VernacularTitle:紫草萘醌类成分的药理活性及其定量分析方法研究进展
- Author:
Min CHENG
1
;
Jun TANG
2
;
Shan-shan LI
2
Author Information
1. Wuhan Institute for Drug and Medical Device Control, Wuhan 430075, China
2. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China
- Publication Type:REVIEWS
- Keywords:
Zicao;
naphthoquinones;
pharmacological action;
quality marker;
quantitative analysis;
quality evaluation
- From:
Acta Pharmaceutica Sinica
2018;53(12):2026-2039
- CountryChina
- Language:Chinese
-
Abstract:
Naphthoquinones are a kind of important active ingredients in the traditional Chinese medicinal herb "Zicao". In recent years, researches on pharmacology and clinical application of naphthoquinones in Zicao have been gradually deepened and made extensive progress around the world. On the other hand, the plant origins of the herbal materials of Zicao in market are complex and their qualities are quite different, thus more and more studies have been focused on the quantitative determination and quality assessment of the medicinal herb as well as its products by using various naphthoquinones as quality chemical markers. In this paper, we review recent advances in the research on pharmacological actions and multi-components content determination of shikonin/alkannin and its derivatives in Zicao so as to provide a scientific guidance for further research and development of medicinal resource of Zicao, and to establish more comprehensive and systematic method for their quality control and evaluation.
