Progress in the study of the function of tribbles homologous protein 3
10.16438/j.0513-4870.2018-0850
- VernacularTitle:Tribbles同源蛋白3的功能研究进展
- Author:
Hui-qiang WANG
1
;
Yu-huan LI
1
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
tribbles homologous protein 3;
tumor;
insulin resistance;
endoplasmic reticulum stress;
inflamemation;
cell differentiation
- From:
Acta Pharmaceutica Sinica
2018;53(12):1986-1994
- CountryChina
- Language:Chinese
-
Abstract:
Tribbles homologous protein 3 (TRB3) has a wide range of biological functions, such as involvement in tumor regulation, the occurrence of insulin resistance, endoplasmic reticulum stress response, inflammation regulation and the regulation of cell growth and differentiation. TRB3, as a key "pressure regulating switch", is involved in the regulation of numerous diseases and serves as a biomarker and potential therapeutic target for many diseases. This paper gives an overview of the research on the biological function of TRB3 in recent years, in order to provide a theoretical basis for further research on TRB3 function.
