Advances in the nonribosomal peptide synthetases
10.16438/j.0513-4870.2018-0170
- VernacularTitle:非核糖体肽合成酶研究进展
- Author:
Meng-yao HAN
1
;
Jing-jing CHEN
1
;
Yun-ming QIAO
1
;
Ping ZHU
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Key Laboratory of Biosynthesis of Natural Products, National Health Commission of PRC, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
nonribosomal peptide;
nonribosomal peptide synthetase;
functional domain;
synthesis mechanism
- From:
Acta Pharmaceutica Sinica
2018;53(7):1080-1089
- CountryChina
- Language:Chinese
-
Abstract:
Nonribosomal peptide synthetases (NRPS) catalyze the synthesis of nonribosomal peptide (NRP) compounds with structural and functional diversities, including more than 20 marketed drugs. This review focuses on the recent advances in the functional domains of NRPS and their mechanisms of action, as well as the unconventional assembly patterns such as iterative NRPS, module skipping, in trans aminoacylation and tandem adenylation domains. This review provides the theoretical basis for exploring new nonribosomal peptide compounds and the development of new drugs.
