Research progresses in pharmacological effects of rhynchophylline and its isomers on nervous system
10.16438/j.0513-4870.2018-0250
- VernacularTitle:钩藤碱及其同分异构体对神经系统作用的研究进展
- Author:
Yan HUANG
1
;
Wen-xia ZHOU
1
;
Yong-xiang ZHANG
1
;
Qin-shi ZHAO
2
Author Information
1. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
- Publication Type:SPECIAL REPORTS
- Keywords:
Uncaria rhynchophylla;
rhynchophylline;
corynoxine;
nervous system;
Alzheimer's disease;
epilepsy
- From:
Acta Pharmaceutica Sinica
2018;53(7):1017-1022
- CountryChina
- Language:Chinese
-
Abstract:
Uncaria rhynchophylla is one of the frequently used herbs in China, it is mainly used for heat-clearance, suppression of hyperactive liver, calming endogenous wind and arresting convulsion in traditional Chinese medicine (TCM). Alkaloids are the main active materials in Uncaria rhynchophylla, pharmacological studies have shown that Uncaria rhynchophylla and its alkaloids have comprehensive biological effects on the nervous system. Rhynchophylline is one of the most abundant alkaloids in Uncaria rhynchophylla. The recent studies demonstrate that rhynchophylline and its isomers (isorhynchophylline, corynoxine, corynoxine B) may be good drug candidates for treatment of Alzheimer's disease, Parkinson's disease, epilepsy, etc. Although the structures of the 4 alkaloids are very similar, they have different effects on nervous system. For example, corynoxine and corynoxine B exhibit better sedative effects than isorhynchophylline. Rhynchophylline and isorhynchophylline have been extensively studied. For development and utilization of rhynchophylline for nervous system disease, more studies are needed to unveil the structure-function relationship and the underlying mechanisms. Here, we summarizes the progresses the effects of rhynchophylline and its isomers on the nervous system.
