Inhibitors of aquaporin 1 and its role in tumor development and progression
10.16438/j.0513-4870.2018-0066
- VernacularTitle:水通道蛋白1在肿瘤进展中的作用及其抑制剂研究进展
- Author:
Zhi-yu ZHANG
1
;
Juan WU
1
;
Xue-jun LI
1
Author Information
1. School of Basic Medical Science, Health Science Center, Peking University, Beijing 100191, China
- Publication Type:REVIEWS
- Keywords:
aquaporin 1;
tumor proliferation;
tumor cell migration;
angiogenesis;
inhibitor
- From:
Acta Pharmaceutica Sinica
2018;53(6):910-919
- CountryChina
- Language:Chinese
-
Abstract:
Aquaporin 1 (AQP1), the first water channel protein discovered among the aquaporin family, is a hydrophobic transmembrane protein involved in transcellular water movement. Recent evidence shows that AQP1 plays a role in tumor cell proliferation and migration, angiogenesis and tumor development and progression, representing a potential therapeutic target. In this review, we discuss the structures, functions and inhibitors of AQP1, as well as the involvement of AQP1 in tumor development and progression.
