Recent advances in the drug formulations of anti-tumor antibiotics

VernacularTitle:抗肿瘤抗生素药物制剂的研究进展
Author: Wei LIU ¹ ; Li-qing CHEN ¹ ; Xin XIN ¹ ; Wei HUANG ¹ ; Zhong-gao GAO ¹
Author Information

1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Publication Type:SPECIAL REPORTS
Keywords: anti-tumor antibiotics; drug carrier; smart delivery system; targeting ability
From: Acta Pharmaceutica Sinica 2018;53(6):865-877
CountryChina
Language:Chinese
Abstract: Anti-tumor antibiotics exhibit great application potential in the anti-tumor therapy. Some drugs have become the first-line medication clinically. However, there are always various problems associated with anti-tumor antibiotics, such as poor solubility and instability as well as severe systemic side effects. It is important to choose suitable delivery carriers for a reasonable delivery system for a good targeting ability, enhanced anti-tumor efficacy and reduced adverse effects of the anti-tumor antibiotics, especially in the smart delivery systems. This review summarizes the carriers and the advances in the delivery systems of anti-tumor antibiotics, including anti-tumor antibiotic drugs currently on the market, in the clinical research stage and in the basic research stage.