Research progress in new anti-tumor drugs on different targets derived from microorganisms
10.16438/j.0513-4870.2018-0202
- VernacularTitle:新型微生物来源的针对不同靶点的抗肿瘤药物研究进展
- Author:
Shu-zhen CHEN
1
;
Yong-su ZHEN
1
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:SPECIAL REPORTS
- Keywords:
anti-tumor active substance;
target;
“warheads” of antibody-drug conjugates
- From:
Acta Pharmaceutica Sinica
2018;53(6):833-838
- CountryChina
- Language:Chinese
-
Abstract:
The metabolites produced by complex and diverse microorganisms are important resources for drug research and development. Using new targets to screen microbial metabolites, many anti-cancer drugs acting on different targets are discovered. Anti-tumor antibiotics acting on various targets and signaling pathways are important members in the study of specific targets for anti-tumor, and some anticancer antibiotics with potent antitumor activity are used as "warheads" of antibody-drug conjugates. Microbial-derived anti-tumor substances acting on different targets with high-efficiency "warheads" molecules are reviewed to provide a literature basis for research on the anti-cancer drugs for specific targets derived from microorganisms.
