Advance in research of biodegradable mesoporous silica nanoparticles
10.16438/j.0513-4870.2017-1181
- VernacularTitle:生物可降解介孔硅纳米粒的研究进展
- Author:
Wei-dong FEI
1
;
Jiao-yang TAO
2
;
Qian-qian SONG
1
;
Yun-chun ZHAO
1
;
Hao-kun YANG
3
;
Jia-zhen ZHU
2
;
Fan-zhu LI
2
Author Information
1. Department of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
2. College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China
3. Second Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
- Publication Type:REVIEWS
- Keywords:
biodegradability;
mesoporous silica nanoparticles;
metal oxide doping method;
organic compound doping method;
biodegradable mechanism
- From:
Acta Pharmaceutica Sinica
2018;53(5):716-726
- CountryChina
- Language:Chinese
-
Abstract:
Mesoporous silica nanoparticles (MSNs) have been widely used as drug carriers in the diagnosis and treatment of diseases due to their specific characteristics, which include a large surface area, ordered mesoporous structures, easy surface modification and feasible sustained release action for encapsulated drugs. With the research development of MSNs, the biodegradability and removability of mesoporous silica nanomaterials have attracted considerable attention in the clinical application of the MSNs-based formulations. This paper was prepared to emphasize the preparation approaches of biodegradable mesoporous silica nanoparticles through the metal oxide doping method and the organic compound doping method. We discussed the biodegradable mechanism and process of such nanoparticles, and finally, provided an insightful and helpful review of the prospective application of the biodegradable mesoporous silica nanoparticles in medical field.
