Role of carboxylesterase in drug metabolism
10.16438/j.0513-4870.2017-0901
- VernacularTitle:哺乳动物羧酸酯酶在药物代谢中的作用
- Author:
Rui WANG
1
;
Jian-wei JIANG
1
;
Yan LI
1
Author Information
1. Department of Drug Metabolism, Beijing City Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Beijing City Key Laboratory of Active Substances Discovery and Drug Ability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
carboxylesterase;
pharmacokinetics;
species difference;
gene polymorphism
- From:
Acta Pharmaceutica Sinica
2018;53(2):186-191
- CountryChina
- Language:Chinese
-
Abstract:
Carboxylesterases (CESs) belong to the esterase family, which are mainly responsible for catalyzing metabolism of a variety of drug as well as endogenous and exogenous compounds. CESs are widely distributed in the body, mainly expressed in lung, liver, intestine, kidney, skin epithelial cells, etc. There are significant species differences in the expression of CESs, which results in the difference on the drug metabolism with genetic polymorphism. In this paper, an overview of the classification and distribution, physiological function and mechanism, species differences and gene polymorphism of CESs are provided for the research of CESs and drug design.
