Role of human liver and intestine esterases in drug design and development
10.16438/j.0513-4870.2017-0823
- VernacularTitle:肝脏和肠道酯酶在药物代谢及新药研发中的作用
- Author:
Jin-fang JIANG
1
;
Xiu-li LI
1
;
Xiao-yan CHEN
1
;
Da-fang ZHONG
1
Author Information
1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
- Publication Type:REVIEWS
- Keywords:
carboxylesterase;
arylacetamide deacetylase;
drug metabolism;
drug design
- From:
Acta Pharmaceutica Sinica
2018;53(2):177-185
- CountryChina
- Language:Chinese
-
Abstract:
Human carboxylesterase (CES) and arylacetamide deacetylase (AADAC) are important numbers of the serine esterase superfamily. They are involved in hydrolytic procedure of human endogenous cholesteryl esters, as well as drug metabolism, activation and detoxication. They are closely related to the personalized medication of drugs, especially for prodrugs. This review summarizes their structure and distribution, metabolic characteristics and research progress in recent years, which will provide a reference for new drug development and rational drug design.
