The roles of deubiquitinating enzymes in cancer therapy
10.16438/j.0513-4870.2017-1166
- VernacularTitle:去泛素化酶在肿瘤中的作用及其抑制剂相关研究进展
- Author:
Guang-han FAN
1
;
Hong ZHU
1
;
Yi-zheng FANG
2
;
Qiao-jun HE
1
Author Information
1. Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
2. Hangzhou No. 14 Middle School, Hangzhou 310006, China
- Publication Type:REVIEWS
- Keywords:
deubiquitinating enzyme;
neoplasm;
deubiquitinating enzymes inhibitor;
protein;
signal transduction
- From:
Acta Pharmaceutica Sinica
2018;53(2):169-176
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitination and deubiquitination play important roles in the regulation of protein stability and function. Deubiquitinating enzymes (DUBs) are involved in the regulation of survival, migration and proliferation of cancer cells, by participating in a variety of signaling pathways. Most of the DUBs promote the malignant transformation and progression, while the others may function as tumor-suppressors. Given the central roles of DUBs in tumorigenesis and malignant progression, some of these enzymes have been regarded as promising anti-cancer targets. This paper reviews the recent advances in tumor-related DUBs and inhibitors.
