Recent advances of nanocarriers in tumor immunotherapy
10.16438/j.0513-4870.2017-0850
- VernacularTitle:纳米载体在肿瘤免疫治疗中的研究进展
- Author:
Man LI
1
;
Yu-ting YANG
1
;
Qin HE
1
;
Zhi-rong ZHANG
1
Author Information
1. West China School of Pharmacy, Sichuan University, Chengdu 610041, China
- Publication Type:REVIEWS
- Keywords:
nanocarrier;
targeted delivery;
immunotherapy;
tumor;
vaccine
- From:
Acta Pharmaceutica Sinica
2017;52(12):1839-1848
- CountryChina
- Language:Chinese
-
Abstract:
In the past 20 years, tumor immunotherapy has made a significant progress in tumor inhibition effects in both laboratory studies and clinical trails. In the immune response to tumor, effective antitumor immunity is induced during the tumor progress; long-term monitoring of the tumor would be achieved through the immune memory, reducing the possibility of tumor recurrence. In the immune treatment strategies, a focus is delivery of therapeutic immune regulators with nanocarriers. It has been demonstrated that due to the special physical and chemical properties, nanocarriers are easily internalized by immune cells, which regulate the immune responses and effectively induce anti-tumor immune cascade to achieve the tumor inhibition effect. In this paper, we will discuss the progress of nanocarrier-mediated antitumor immunotherapy in recent years.
