Research progress in instability mechanism and stabilizer of anthocyanins in oral liquid preparation of traditional Chinese medicine
10.16438/j.0513-4870.2017-0331
- VernacularTitle:中药口服液体制剂中花青素不稳定机制及稳定剂研究进展
- Author:
Hao-zhou HUANG
1
;
Ding-kun ZHANG
1
;
Hong JIANG
1
;
Jun-zhi LIN
2
;
Ya-nan HE
1
;
Run-chun XU
1
;
Ming YANG
3
;
Li HAN
1
Author Information
1. Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
2. Central Laboratory, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
3. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
- Publication Type:REVIEWS
- Keywords:
anthocyanins;
oral liquid;
stabilizer;
clarity;
degradation
- From:
Acta Pharmaceutica Sinica
2017;52(10):1524-1532
- CountryChina
- Language:Chinese
-
Abstract:
Anthocyanins has a high health benefits and biological activity, which can make the solution easily absorbed and has a bright color, beautiful appearance in oral liquid. However, due to its particularity antioxidant activity, it is easy to be affected by the external physical and chemical factors, and then oxidation, polymerization, degradation and other unstable phenomena occurs that seriously affect the stability of products and shelf life. The traditional methods of pH regulation, deoxygenation and light avoidance could not meet the demand of stable anthocyanins. Addition of stabilizer to anthocyanins is a new effective way to improve the stability of anthocyanins. This paper is prepared to summarize systematically the principle and application methods of anthocyanins stabilizers to explore the key technology of clarification and stabilization of traditional Chinese medicine in the natural oral liquid, which may provide theoretical support and technical reference for the development and utilization of anthocyanins stabilizer.
